This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N Engl J Med 2016; 375: 1845-1855.
Published: 16th January 2017
Authors: Eggermont AMM, Chiarion-Sileni V, Grob J-J, Dummer R, Wolchok JD, Schmidt H et al.
Conclusion
Some 951 patients were included. At five year follow-up, patients treated with ipilimumab had improved recurrence-free (40.8 versus 30.3 per cent, P<0.001) and overall survival (65.4 versus 54.4 per cent, P=0.001). But 42 per cent of patients on ipilimumab had immune-related adverse events, five of which were fatal.
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