This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Prospective, randomized trial comparing 5-FU/LV with or without oxaliplatin as adjuvant treatment following curative resection of gastric adenocarcinoma. Eur J Surg Oncol 2011; 37: 466–472.

Published: 27th September 2011

Authors: Zhang X-L, Shi H-J, Cui S-Z, Tang Y-Q, Ba M-C.

Conclusion

Two different chemotherapy regimens were compared in 80 patients. The addition of oxaliplatin improved recurrence-free (30 versus 16 months, P<0.05) and overall survival (36 versus 28 months, P<0.05), but 19 per cent rate of the patients developed peripheral neuropathy.

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IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

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Authors: Lu J, Zheng C-H, Xu B-B, Xie J-W, Wang J-B, Lin J-X et al.