The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomised controlled trial of mesalazine in IBS. Gut 2016; 65: 82-90.

Published: 13th July 2016

Authors: Giovanni B, Cremon C, Annese V, Basilisco G, Bazzoli M, et al. et al.

Conclusion

Some 185 patients with IBS (irritable bowel syndrome) were treated for 12 weeks. Response rates were similar with mesalazine (68.6 per cent) and placebo (67.4 per cent). A small subgroup of patients did report sustained improvement.

Pubmed Link

You may also be interested in

Scientific Surgery

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: retrospective long-term follow-up of the LIR!C trial. Lancet Gastroenterol Hepatol 2020; 5: 900-907.

Authors: Stevens TW, Haasnoot GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ et al.

Scientific Surgery

Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol 2020; 5: 658-666.

Authors: Andreson V, Gschossmann J, Layer P

Scientific Surgery

Efficacy of soluble fibre, antispasmodic drugs and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol 2020; 5: 117-131.

Authors: Black CJ, Yuan Y , Selinger CP, Camilleri CP, Quigley EMM, Moayyedi P et al.

Scientific Surgery

Efficacy of preoperative oral antibiotic prophylaxis for the prevention of surgical site infections in patients with Crohn’s Disease. A Randomized Controlled Trial. Ann Surg 2019; 269: 420-426.

Authors: Uchino M, Ikeuchi H, Bando T, Chohno T, Sasaki H, Horio Y et al.

Scientific Surgery

Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet 2017; 390: 2779-2789.

Authors: Colombel J-F, Panaccione R, Bossuyt P, Lukas M, Baert F, Vaňásek T et al.

Scientific Surgery

A mechanistic multicentre, parallel group randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D). Gut 2016; 65: 91-99.

Authors: Lam C, Tan W, Leighton M, Hastings M, Lingaya M, Falcone Y et al.

Scientific Surgery

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Gut 2014; 63: 1617-1625.

Authors: Garsed K, Chernova J, Hastings M, Lam C, Marciani L, Singh G et al. et al.

Scientific Surgery

A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn’s disease. Gut 2013; 62: 1288–1294.

Authors: Sands BE, Katz S, Wolf DC, Feagan BG, Wang T, Gustofson LM et al. et al.

Scientific Surgery

HAnd suture versus STApling for closure of loop ileostomy (HASTA Trial): results of a multicenter randomized trial. Ann Surg 2012; 256: 828–836.

Authors: Loffler T, Rossion I, Bruckner T, Diener MK, Koch M, von Frankenberg M et al. et al.

Scientific Surgery

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut 2011; 60: 902–914.

Authors: Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O’Keefe SJ. et al.

Scientific Surgery

Infliximab, azathioprine or combination therapy for Crohn’s Disease.  N Engl J Med 2010; 362: 1383-95.

Authors: Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kombluth A, Rachmilewitz D et al. et al.

Scientific Surgery

Long term outcomes of laparoscopic versus open ileocolic resection for Crohn’s Disease: follow-up of a prospective randomized trial Surgery 2008; 144: 622-628

Authors: Stocchi L, Milsom JW, Fazio VW