The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut 2011; 60: 902–914.

Published: 21st December 2011

Authors: Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O’Keefe SJ. et al.

Conclusion

The study included two different doses of teduglutide and a placebo arm in 83 patients. The lower dose (0.05mg/kg/day) significantly reduced parenteral fluid requirements.

Pubmed Link