This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion. Br J Surg 2001; 88: 1066-72.

Published: 1st January 2001

Authors: Vammnen S, Lindholt JS, Ostergaard L, Fasting H, Henneberg EW.

Conclusion

Ninety-two subjects with a small aneurysm were followed for a mean of 1.5 years. Mean annual expansion rate was significantly lower after antibiotic therapy (1.56mm vs. 2.75mm, p=0.02)

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A multicenter, prospective randomized trial of negative pressure wound therapy for infrainguinal revascularization with a groin incision. J Vasc Surg 2021; 74: 257-267.

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Abelacimab for prevention of venous thromboembolism. N Engl J Med 2021; 385: 609-617.

Authors: Verhamme P, Yi BA, Segers A, Salter J, Bloomfield D, Buller HR et al.

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An indirect comparison by Bayesian network meta-analysis of drug-coated devices versus saphenous vein graft bypass in femoropopliteal arterial occlusive disease. J Vasc Surg 2021; 74: 478-486.

Authors: Zhang R, Ni L, Zeng R, Lai Z, Di X, Zhao Z et al.

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Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy. Lancet 2021; 398: 1065-1073.

Authors: Halliday A, Bulbia R, Bonati LH, Chester J, Cradduck-Bamford A, Peto R et al.

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Network meta-analysis of drug-coated balloon angioplasty versus primary nitinol stenting for femoropopliteal atherosclerotic disease. J Vasc Surg 2021; 73: 1802-1810.

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Intermittent pneumatic compression in addition to standard prophylaxis of postoperative venous thromboembolism in extremely high-risk patients (IPC SUPER): a randomized controlled trial. Ann Surg 2021; 274: 63-69.

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A randomized controlled trial of treatment with intermittent negative pressure for intermittent claudication. J Vasc Surg 2021; 73: 1750-8.

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Effect of low-intensity vs high-intensity home-based walking exercise on walk distance in patients with peripheral artery disease. The LITE Randomized Clinical Trial. JAMA 2021; 325: 1266-1276.

Authors: McDermott MM, Spring B, Tian L, Treat-Jacobsen D, Ferrucci L, Lloyd-Jones D et al.

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Systematic review and meta-analysis of wound adjuncts for the prevention of groin wound surgical site infection in arterial surgery. Eur J Vasc Endovasc Surg 2021; 61: 636-646.

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Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. J Vasc Surg Venous Lymphatic 2020; 8: 978-989.

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