This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomized trial of medical versus surgical treatment for refractory heartburn. N Engl J Med 2019; 381: 1513-1523

Published: 23rd December 2019

Authors: Spechler SJ, Hunter JG, Jones KM, Lee RL, Smith BR, Mashimo H et al.

Conclusion

Of 366 patients initially included, 78 were still symptomatic after treatment with omeprazole, and were randomized to surgery, or continued medicine. After one year, treatment success was greater after surgery (67 per cent) than active medical treatment (28 per cent, P=0.07), or controls continuing omeprazole (12 per cent, P<0.001).

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