This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Restrictive versus liberal fluid therapy for major abdominal surgery. N Engl J Med 2018; 378: 2263-2274.

Published: 9th August 2018

Authors: Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D et al.

Conclusion

Median intravenous fluid intake was lower in the restricted (3.7 Li) than the liberal fluid group (6.1 Li) in this study of 3000 procedures. Acute kidney injury was reduced in the liberal fluid group (P<0.001), as was the rate of surgical site infection (P=0.02). Disability-free survival at one year was similar.

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Low versus standard urine output targets in patients undergoing major abdominal surgery: a randomized noninferiority trial. Ann Surg 2017; 265: 874-881.

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