This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Rivaroxaban or aspirin for extended treatment of venous thromboembolism. N Engl J Med 2017; 376: 1211-1222.

Published: 26th April 2017

Authors: Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Bayer-Westendorf J, Bounameaux H et al.

Conclusion

Some 3396 patients who completed their initial anticoagulation were randomized to aspirin or rivaroxaban for a further twelve months. Recurrent symptomatic venous thromboembolism was more common in patients on aspirin: 4.4 versus 1.5 per cent on 20mg and 1.2 per cent on 10mg rivaroxaban (P<0.001 for both doses). Major bleeding rates were similar.

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