This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Saline vs tissue plasminogen activator irrigations after drain placement for appendicitis-associated abscess: a prospective randomized trial. J Am Coll Surg 2015; 221: 390–396.

Published: 5th January 2016

Authors: St Peter SD, Shah SR, Adibe OO, Sharp SW, Reading B, Cully B et al. et al.

Conclusion

Twice daily instillation of tPA was not beneficial in this study that included 62 children. It did not reduce days of drainage or days of antibiotics, and actually increased duration of hospital stay.

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