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Tailoring adjuvant endocrine therapy for premenopausal breast cancer. N Engl J Med 2018; 379:122-137.

Published: 17th September 2018

Authors: Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Lang I et al.


This update of two large RCTs showed that the addition of ovarian suppression to tamoxifen improved disease-free and overall survival after eight years. The further addition of exemestane resulted in even higher rates of freedom from recurrence. Ovarian suppression did increase the frequency of adverse events.

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