This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Tailoring adjuvant endocrine therapy for premenopausal breast cancer. N Engl J Med 2018; 379:122-137.
Published: 17th September 2018
Authors: Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Lang I et al.
Conclusion
This update of two large RCTs showed that the addition of ovarian suppression to tamoxifen improved disease-free and overall survival after eight years. The further addition of exemestane resulted in even higher rates of freedom from recurrence. Ovarian suppression did increase the frequency of adverse events.
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