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Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. The PROPPR randomized clinical trial. JAMA 2015; 313: 471-482.

Published: 14th April 2015

Authors: Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM et al. et al.


In this study that included 680 patients, early resuscitation with the 1:1:1 regimen did not affect the primary trial endpoint (death within 30 days: 22.4 versus 26.1 per cent), but did improve haemostasis, and reduce the rate of death from exsanguination within 24h.

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