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Transfusion strategies for acute upper gastrointestinal bleeding.  N Engl J Med 2013; 368: 11-21.

Published: 30th July 2013

Authors: Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C et al. et al.


Some 921 patients were randomized to one of two blood transfusion triggers: 7g/dL or 9g/dL. Survival after six weeks was higher in the 7g/dL group: 95 versus 91 per cent (hazard ratio 0.55, 95 per cent confidence interval 0.33 to 0.92, P=0.02). Risk of rebleeding was also lower (10 versus 16 per cent, P=0.01), and complications were fewer (40 versus 48 per cent, P=0.02).

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