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Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet 2020; 396: 167-176.

Published: 16th September 2020

Authors: Schepers NJ, Hallensleben NDL, Besselink MG, Anten M-PG, Bollen TL, da Costa DW et al.


Early intervention did not reduce the risk of death or major complications in this study that included 232 patients with predicted severe pancreatitis, but without cholangitis: 38 per cent after ERCP versus 44 per cent with conservative treatment (P=0.37).

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