This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Surgical management of idiopathic perianal fistulas: a systematic review and meta-analysis. Dig Surg 2021; 38: 104-119.

Published: 24th November 2021

Authors: Cheung XC, Fahey T, Rogers AC, Pemberton JH, Kavanagh DO

Conclusion

This analysis included 28 RCTs. There was no significant difference in rates of incontinence between the various surgical approaches, but there were higher recurrence rates when glue or plugs were employed.

Pubmed Link

You may also be interested in

Scientific Surgery

A multicenter randomized controlled trial comparing safety, efficacy, and cost-effectiveness of the Surgisis Anal Fistula Plug versus surgeon’s preference for trans sphincteric fistula-in-ano. The FIAT Trial. Ann Surg 2021; 273: 433-441.

Authors: Jayne D, Scholefield J, Tolan D, Gray R, Senapati A, Hulme CT et al.

Scientific Surgery

Drainage Seton versus external anal sphincter-sparing Seton after rerouting of the fistula tract in the treatment of complex anal fistula: a randomized controlled trial. Dis Colon Rectum 2019; 62: 980-987

Authors: Omar W, Alqasaby A, Abdelnaby M, Youssef M, Shalaby M, Anwar Abdel-Razik M et al.

Scientific Surgery

Topical minoxidil versus topical diltiazem for chemical sphincterotomy of chronic anal fissure: a prospective, randomized, double-blind, clinical trial. World J Surg 2018; 42: 2252–2258.

Authors: Alvandipour M, Ala S, Khalvati M, Yazdanicharati J, Koulaeinejad N

Scientific Surgery

Autologous myoblasts for the treatment of fecal incontinence; results of a phase 2 randomized placebo-controlled study (MIAS). Ann Surg 2018; 267: 443–450.

Authors: Boyer O, Bridoux V, Giverne C, Bisson A, Koning E, Leroi A-M et al.

Scientific Surgery

Antibiotic therapy for prevention of fistula in-ano after incision and drainage of simple perianal abscess: a randomized single blind clinical trial. Surgery 2017; 162: 1017-1025.

Authors: Ghahramani L, Minaie MR, Arasteh P, Hosseini SV, Izadpanah A, Bananzadeh AM et al.

Scientific Surgery

Temperature-controlled delivery of radiofrequency energy in fecal incontinence: a randomized sham-controlled clinical trial. Dis Colon Rectum 2017; 60: 860-865.

Authors: Visscher A, Lam T, Meurs-Szojda MM, Felt-Bersma R

Scientific Surgery

Bowel function after laparoscopic sutured rectopexy versus ventral mesh rectopexy for rectal proplapse: a double-blind, randomised single-centre study. Lancet Gastoenterol Hepatol 2016; 1: 291-297.

Authors: Lundby L, Iverson LH, Buntzen S, Wara P, Hoyer K, Laurberg S et al.

Scientific Surgery

Ligation of intersphincteric fistula tract vs ligation of the intersphincteric fistula tract plus a bioprosthetic anal fistula plug procedure in patients with transsphincteric anal fistula: early results of a multicenter prospective randomized trial. Ann Surg 2016; 264: 917-922.

Authors: Han JG, Wang ZJ, Zheng Y, Chen CW, Wang XQ, Che XM et al.

Scientific Surgery

Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet 2016; 388: 1281–1290.

Authors: Panes J, Garcia-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC et al.

Scientific Surgery

Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet 2016; 388: 1281–1290.

Authors: Panes J, Garcia-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC et al.

Scientific Surgery

Short-term outcomes of a randomized pilot trial of 2 treatment regimens of transcutaneous tibial nerve stimulation for fecal incontinence. Dis Colon Rectum 2015; 58: 974-982.

Authors: Rimmer CJ, Knowles CH, Lamparelli M, Durdey P, Lindsey I, Hunt L et al. et al.

Scientific Surgery

Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults (CONFIDeNT): a double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial. Lancet 2015; 386: 1640–1648.

Authors: Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O’Connell PR et al on behalf of the CONFIDeNT study group et al.