This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Published: 7th May 2021

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Conclusion

This study that included 248 procedures found no difference in clinical outcomes (pancreatic fistula, delayed gastric emptying, ileus etc) or postoperative pain levels between the groups.

Pubmed Link

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Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

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Effect of hydrocortisone vs pasireotide on pancreatic surgery complications in patients with high risk of pancreatic fistula. A randomized clinical trial. JAMA Surg 2020; 155: 291-298.

Authors: Tarvainen T, Siren J, Kokkola A, Sallinen V

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Results of a randomized controlled trial comparing closed-suction drains versus passive gravity drains after pancreatic resection. Surgery 2018; 164: 1057-1063.

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Minimally invasive versus open distal pancreatectomy (LEOPARD). A multicenter patient-blinded randomized controlled trial. Ann Surg 2019; 269: 2-9.

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Comparison of perioperative outcomes between laparoscopic and open approach for pancreatoduodenectomy: the PADULAP randomized controlled trial. Ann Surg 2018; 268: 731-739.

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A Prospective randomized multicenter trial of distal pancreatectomy with and without routine intraperitoneal drainage. Ann Surg 2017; 266: 421-431.

Authors: Van Buren G , Bloomston M, Schmidt CR, Behrman SW, Zyromski NJ, Ball C et al.