The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial. Lancet Oncol 2017; 18: 357-370.

Published: 26th April 2017

Authors: Cunningham D, Stenning SP , Smyth EC, Okines AF, Allum WH, Rowley S et al.

Conclusion

In this trial that included 1063 patients, the addition of bevacizumab did not improve 3-year survival: 48.1 per cent compared to 50.3 per cent in the standard chemotherapy group (P=0.36). More patients in the bevacizumab group had an anastomotic leak after oesophagectomy: 24 versus 10 per cent.

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