This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of N-acetylcysteine on liver recovery after resection: A randomized clinical trial. J Surg Oncol 2016; 114: 446–450.

Published: 20th December 2016

Authors: Grendar J, Ouellet JF, McKay A, Sutherland FR, Bathe OF, Ball CG et al.

Conclusion

This study was terminated after 206 patients were randomized because of safety concerns. NAC did not affect hepatic failure or overall complications, but did seem to increase the risk of postoperative delirium 9.8 versus 2.7 per cent, P<0.05.

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