This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Handcrafted vacuum-assisted device for skin ulcers treatment versus traditional therapy, randomized controlled trial. World J Surg 2017; 41: 386–393.

Published: 14th June 2017

Authors: Gonzalez IG, Angel MAL, Baez MVJ, Flores BR, Ferretiz MDM, Woolf SV et al.

Conclusion

Use of the home-made device improved the rate of wound healing and reduced the inflammatory response in this study that included 126 patients.

Pubmed Link

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A randomized trial of class 2 and class 3 elastic compression in the prevention of recurrence of venous ulceration. J Vacs Surg Venous Lymphat Disord 2018; 6: 717–723.

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A randomized trial of early endovenous ablation in venous ulceration. N Engl J Med 2018; 378: 2105-2114.

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Clinical and cost-effectiveness of compression hosiery versus compression bandages in treatment of venous leg ulcers (Venous leg Ulcer Study IV, VenUS IV): a randomised controlled trial. Lancet 2014; 383:871-879.

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The influence of patient and wound variables on healing of venous leg ulcers in a randomized controlled trial of growth-arrested allogeneic keratinocytes and fibroblasts. J Vasc Surg 2013; 58: 433–439.

Authors: Lantis JC, Marston WA, Farber A, Kirsner RS, Zhang Y, Lee TD et al. et al.

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Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2012; 380: 977–985.

Authors: Kirsner RS, Marston WA, Snyder RJ, Lee TD, Cargill DI, Slade HB et al.

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Use of weekly, low dose, high frequency ultrasound for hard to heal venous leg ulcers: the VenUS III randomised controlled trial. BMJ 2011; 342: 585.

Authors: Watson JM, Kang’ombe AR, Soares MO, Chuang L-H, Worthy G, Bland JM et al. et al.

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Modern wound care for the poor: a randomized clinical trial comparing the vacuum system with conventional saline soaked gauze dressings. Am J Surg 2010; 199: 14-20.

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Randomised clinical trial of foam sclerotherapy in patients with a venous leg ulcer. Eur J Vasc Endovasc Surg 2010; 39: 495-499.

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