This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial. Lancet 2016; 387: 2293–2301.

Published: 7th September 2016

Authors: Luo H, Zhao L, Leung J, Zhang R, Liu Z, Wang X et al.

Conclusion

In this study that included 2600 procedures, routine pre-intervention indomethacin reduced the rate of pancreatitis to 4 per cent, compared to 8 per cent in patients who had the drug postoperatively selectively, depending on risk; P<0.0001.

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