This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. Lancet 2015: 386: 1351-1361.

Published: 5th January 2016

Authors: Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

Conclusion

Using data from almost 19 thousand women, biphophonates were only of definite benefit in postmenopausal women. In this group they reduced bone recurrence (risk ratio 0.72, 95 per cent confidence interval 0.6 to 0.86, P=0.0002) and breast cancer mortality (0.82, 0.73 to 0.93, P=0.002).

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