This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-forward): 5-year efficacy and late normal tissue effects results from a multicenter, non-inferiority, randomised, phase 3 trial. Lancet 2020; 395: 1613-1626.

Published: 22nd July 2020

Authors: Brunt AM, Haviland JS, Wheatley DA, Sydenham MA, Alhasso A, Bloomfield DJ et al.

Conclusion

A total of 4096 patients were randomly allocated one of three schedules of radiotherapy over one to three weeks. After a median follow-up of 71.5 months, the risk of ipsilateral breast cancer recurrence was non-inferior, and breast tissue effects were least, for the one week schedule of 26 Gy fractions.

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