This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med 2015; 372: 436-446.
Published: 14th April 2015
Authors: Francis PA, Regan MM, Fleming GF, Láng I, Ciruelos E, Bellet M et al. et al.
Conclusion
This study included 3066 women randomized into one of three groups: tamoxifen alone, tamoxifen plus ovarian suppression and exemestane plus ovarian suppression. At five years, disease-free survival was similar: 84.7, 86.6 and 85.7 per cent, respectively. Most recurrences occurred in women who had received chemotherapy.
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