This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet 2015; 386: 1341–1352.

Published: 5th January 2016

Authors: Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

Conclusion

In an analysis that included almost 32 thousand postmenopausal women, aromatase inhibitors reduced recurrence rates by about 30 per cent compared with tamoxifen. Five years of aromatase inhibitor reduced ten year breast cancer mortality by 40 per cent compared to placebo.

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