This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Breast-conserving treatment with or without radiotherapy in ductal carcinoma in situ: 15-year recurrence rates and outcome after a recurrence from the EORTC 10853 randomized phase III trial. J Clin Oncol 2013; 31: 4054-4059.
Published: 15th May 2014
Authors: Donker M, Litiere S, Werutsky G, Julien J-P, Fentiman IS, Agresti R et al. et al.
Conclusion
Some 1010 women with DCIS <5cm were followed for a median 15.8 years. Radiotherapy reduced local recurrence by 48 per cent (hazard ratio 0.52, 95 per cent confidence interval 0.4 to 0.68; P<0.01), but did not affect breast cancer-specific survival: hazard ratio 1.07, 0.6 to 1.91.
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