This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Comparison of doxorubicin and cyclophosphamide versus single agent paclitaxel as adjuvant therapy for breast cancer in women with 0 to 3 positive axillary nodes: CALGB 40101 (Alliance). J Clin Oncol 2014; 32: 2311-2317.
Published: 18th December 2014
Authors: Schulman LN, Berry DA, Cirrincione CT, Becker HP, Perez EA, O'Regan R et al. et al.
Conclusion
Each regimen was given for 4-6 cycles in a total of 3871 women. Although the single agent was less toxic, relapse-free survival (hazard ratio 1.26) and overall survival (1.27) was non significantly better at five years with the dual regimen.
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