This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Double-blind, placebo-controlled, multicentre, randomized phase IIB neoadjuvant study of letrazole-lepatinib in postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2 negative, operable breast cancer. J Clin Oncol 2014; 32: 1050-1057.

Published: 18th December 2014

Authors: Guameri V, Generali DG, Frassoldati A, Boni C, Cavanna L, Tagliafico E et al. et al.

Conclusion

In this study that included 92 women, the use of the new combination for six months improved the rate of complete or partial response compared with letrazole alone from 63 to 70 per cent. Response was improved for tumours with the PIK3CA mutation.

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Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer. N Engl J Med 2021; 384: 2394-2405.

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Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised double-blind, phase 3 trial. Lancet 2020; 396: 1090-1100.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

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