This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Efficacy of adjuvant trastuzumab for patients With human epidermal growth factor receptor 2–positive early breast cancer and tumors ≤ 2 cm: a meta-analysis of the randomized trastuzumab trials. J Clin Oncol 2015; 33: 2600-2608.

Published: 8th March 2016

Authors: O’Sullivan CC, Bradbury I, Campbell C, Spielmann M, Perez EA, Joensuu H et al. et al.

Conclusion

There were five RCTs that included 2263 patients, with median follow-up eight years. Trastuzumab reduced the risk of recurrence (17.3 versus 24.3 per cent; P<0.001) and improved overall mortality (7.8 versus 11.6 per cent; P=0.005).

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Phase III randomized trial of bisphosphonates as adjuvant therapy in breast cancer: S0307. J Natl Cancer Inst 2020; 112: 698-707.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

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