This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial. Lancet 2015; 385:1863–1872.
Published: 23rd June 2015
Authors: Del Mastro L, De Placido S, Bruzzi P, De Laurentis M, Boni C, Cavazzini G et al. for the Gruppo Italiano Mammella (GIM) investigators et al.
Conclusion
Some 2091 women with operable node positive breast cancer were enrolled. Dose-dense chemotherapy (every 2 weeks, instead of every 3 weeks) improved overall survival after median follow-up of seven years: 94 versus 89 per cent; P=0.001. Survival was unaffected by addition of fluorouracil to standard chemotherapy.
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