This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Fluorouracil, doxorubicin and cyclophosphamide (FAC) versus FAC followed by weekly paclitaxel as adjuvant therapy for high-risk, node negative breast cancer: results from the GEICAM/2003-02 Study. J Clin Oncol 2013; 31: 2593-2599.

Published: 3rd October 2013

Authors: Martin M, Ruiz A, Borrego MR, Barnadas A, Gonzales S, Calvo L et al. et al.

Conclusion

A total of 1925 women were included in this study and followed for a median 63.3 months. The addition of paclitaxel caused a small but significant improvement in disease-free survival from 93 to 90.3 per cent (hazard ratio 0.73, 95 per cent confidence interval 0.54 to 0.99 per cent, P=0.04), but no effect on overall survival.

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