This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

High-dose chemotherapy with autologous hematopoietic stem-cell transplantation in metastatic breast cancer: overview of six randomised trials. J Clin Oncol 2011; 29: 3224–3231.

Published: 14th February 2012

Authors: Berry DA, Ueno NT, Johnson MM, Lei X, Caputo J, Smith DA et al. et al.

Conclusion

Six randomized trials were identified. Although better progression-free survival was reported in some trials, this did not translate into an improvement in overall survival: median 2.16 versus 2.02 years, P=0.08. Any benefit from high dose chemotherapy was small.

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