This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Lanreotide autogel 90mg and lymphorrhea prevention after axillary node dissection in breast cancer: A phase III double blind, randomised placebo-controlled trial. Eur J Surg Oncol 2012; 38: 902-909.

Published: 11th February 2013

Authors: Gauthier T, Garuchet-Bigot A, Marin B, Mollard J, Loum O, Fermeaux V et al. et al.

Conclusion

The application of lanreotide on the day before surgery did not reduce the rate of lymphatic drainage in the first four days (median 292ml versus 337 ml in placebo, P=0.18) in this trial that included 148 patients.

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Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer. N Engl J Med 2021; 384: 2394-2405.

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Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised double-blind, phase 3 trial. Lancet 2020; 396: 1090-1100.

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Phase III randomized trial of bisphosphonates as adjuvant therapy in breast cancer: S0307. J Natl Cancer Inst 2020; 112: 698-707.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

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