This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet 2012; 381: 805–816.

Published: 9th May 2013

Authors: Davis C, Pan H, Godwin J, Gray R, Arriagada R, Raina V et al. et al.

Conclusion

Some 12894 women were included. Continued tamoxifen had no effect on oestrogen receptor negative breast cancer, but in receptor positive breast cancer, an additional five years of tamoxifen reduced the rate of death from breast cancer: 331 versus 397 deaths, P=0.01.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

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