This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention. JAMA 2006; 295: 2742-2751.

Published: 1st January 2006

Authors: Land SR, Wickerham DL, Costantino JP, Ritter MW, Vogel VG, Myoungkeun L et al. et al.

Conclusion

There were no major differences in symptoms between the groups in the 20 000 women studied. Women on tamoxifen had more gynaecological symptoms, leg cramps, vasomotor symptoms and bladder problems. Those on raloxifene had more musculoskeletal problems, dyspareunia and weight gain.

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