This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Pharmacological modulation of ischemic-reperfusion injury during Pringle maneuver in hepatic surgery. A prospective randomized pilot study. World J Surg 2016; 40: 2202–2212.

Published: 16th January 2017

Authors: Donadon M, Molinari AF, Corazzi F, Rocchi L, Zito P, Cimino M et al.

Conclusion

During Pringle, patients received either N-acetyl cysteine, methylprednisolone or placebo. Both active medications improved liver function postoperatively compared with placebo if the Pringle lasted more than 70 min in this study that included 48 patients.

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