This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Risk-adapted targeted intra-operative radiotherapy versus whole breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet 2014; 383: 603-613.
Published: 13th November 2014
Authors: Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M et al. et al.
Conclusion
Some 3451 women were included in this multicentre study. Intra-operative radiotherapy (IORT) was associated with fewer radiotherapy skin reactions (P=0.03). At median follow-up of 2 years and five months, there were no differences in cancer specific, or overall survival. Five-year local recurrence was higher after IORT: 3.3 versus 1.3 per cent, P=0.042.
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