This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Selective oestrogen receptor modulators in prevention of breast cancer: an update meta-analysis of individual participant data. Lancet 2013; 381: 1827-1834.
Published: 9th July 2013
Authors: Cuzik J, Sestak I, Bonanni B, Costantino JP, Cummings S, De Censi A et al. et al.
Conclusion
This study included 83,399 women followed for a median of 65 months. The medications reduced the rate of breast cancer during treatment, and for at least five years after, by 38 per cent: hazard ratio 0.62, 95 per cent confidence interval 0.56 to 0.69. The reduction decreased in years 5-10 after treatment. Thromboembolic complications were increased: odds ratio 1.73, 1.47 to 2.05.
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