This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet 2016; 387: 341-348

Published: 29th March 2016

Authors: Ohuchi N, Suzuki A, Sobue T, Kawai M, Yamamoto S, Zheng Y-F et al for the J-START investigator groups et al.

Conclusion

The addition of ultrasound imaging to standard mammography in this study that included 72,998 women increased the detection of breast cancer: 0.5 versus 0.32 per cent, P=0.0003. It also reduced the rate of subsequent interval cancers: 0.05 versus 0.1 per cent, P=0.034.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

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