This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Six cycles of doxorubicin and cyclophosphamide or paclitaxel are not superior to four cycles as adjuvant chemotherapy for breast cancer in women with zero to three positive axillary nodes: Cancer and Leukemia Group B40101. J Clin Oncol 2012; 30: 4071–4076.
Published: 16th April 2013
Authors: Shulman LN, Cirrincione CT, Berry DA, Becker HP, Perez EA O’Regan R, et al. et al.
Conclusion
There was no evidence that extending the duration of chemotherapy was beneficial in this study that included 3171 patients. After median follow-up of 5.3 years, relapse-free survival rates were 91 per cent and 92 per cent after six and four cycles, respectively.
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