This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Systematic review: comparative effectiveness of medications to reduce risk for primary breast cancer Ann Int Med 2009; 151: 703-715

Published: 1st January 2009

Authors: Nelson HD, Fu, R, Griffin JC, Nygren P, Smith B et al.

Conclusion

Eight trials were included in the analysis; three drugs reduced the risk of breast cancer. These were tamoxifen (risk ratio 0.7, 95 per cent confidence interval 0.59 to 0.82), raloxifene (0.44, 0.27 to 0.71) and tibolone (0.32, 0.13 to 0.8). Each drug, however, had its individual counterbalancing risk profile.

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