This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2. JAMA 2001; 286: 2251- 6.
Published: 1st January 2001
Authors: King M-C, Wieand S, Hale K, Lee M, Walsh T, Owens K et al.
Conclusion
Within a randomized trial of breast cancer prevention with tamoxifen, 19 women with BRCA genetic mutations who developed breast cancer were examined. Tamoxifen reduced the rate of cancer by 62 per cent, similar to the rate in all women in the trial
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