This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Tamoxifen for the prevention of breast cancer: late results of the Italian Randomised Tamoxifen Prevention Trial among women with hysterectomy. J Natl Cancer Inst 2007; 99: 727-737.
Published: 1st January 2007
Authors: Veronesi U, Maisonneuve P, Rotmensz N, Bonanni B, Boyle P, Viale G et al.
Conclusion
Over 5000 women were originally randomized. After eleven years of follow-up, the relative risk of developing breast cancer was 0.84, 95 per cent confidence interval 0.6 to 1.17. In high risk women, tamoxifen was more effective: relative risk 0.24, 0.1 to 0.59.
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