This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
The UK Standardisation of Breast radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol 2013; 14: 1086-1094.
Published: 12th December 2013
Authors: Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, Barrett-Lee PJ et al. et al.
Conclusion
These two studies recruited almost five thousand women. They showed that lower total dose, higher fractionation radiotherapy was not associated with inferior local recurrence rates. Local tissue effects were reduced in the 40Gy, 15 fractions over three weeks radiotherapy group, which is now standard of care.
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