This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Timing of adjuvant surgical oophorectomy in the menstrual cycle and disease-free and overall survival in premenopausal women with operable breast cancer. J Natl Cancer Inst 2015; 107

Published: 11th February 2016

Authors: Love RR, Laudico AV, Van Dinh N, Allred DC, Uly GB, Quang LH et al. et al.

Conclusion

Some 509 women due to have oophrectomy, who were not in the luteal phase of the menstrual cycle were randomized to early or delayed surgery. After five years, luteal phase oophrectomy had no survival advantage: 64 versus 71 per cent (P=0.18). There was actually an improvement in disease-free survival after follicular phase surgery on multivariable analysis.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

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