This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Twenty-five year follow-up for breast cancer incidence and mortality of the Canadian National breast Screening Study: a randomised trial. BMJ 2014: 348: g366.

Published: 11th September 2014

Authors: Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA et al.

Conclusion

Almost 90,000 women aged 40-59 were randomized into this study of screening versus normal care, including physical examination. Cumulative mortality from all breast cancers diagnosed during the study was similar in both groups: hazard ratio 0.99, 95 per cent confidence interval 0.88 to 1.12.

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Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised double-blind, phase 3 trial. Lancet 2020; 396: 1090-1100.

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West German Study Plan B Trial: adjuvant four cycles of epirubicin and cyclophosphamide plus docetaxel versus six cycles of docetaxel and cyclophosphamide in HER2-negative early breast cancer. J Clin Oncol 2019; 37: 799-808

Authors: Nitz M, Gluz O, Clemens M, Malter W, Reimer T, Nuding B et al.