This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial. Lancet 2000; 356: 2059-63.

Published: 1st January 2000

Authors: Loprinzi CL, Kugler JW, Sloan JA, Mailliard JA, LaVasseur BI, Barton DL et al. et al.

Conclusion

Some 222 women were randomized into one of four groups, placebo or one of three doses of this antidepressant drug. Active treatment reduced the rate of flushing by 37-61 per cent, at the expense of symptoms such as dry mouth and occasional nausea

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