This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
11 years’ follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial. Lancet 2017; 389: 1195–1205.
Published: 26th April 2017
Authors: Cameron D, Piccart-Gebhart M, Gelber RD, Procter M, Goldhirsch A, de Azambuja E et al.
Conclusion
The study included 5099 women followed for a median of 11 years. One year of trastuzumab improved disease-free (hazard ratio 0.76, 95 per cent confidence interval 0.68 to 0.86) and overall survival (0.74, 0.64 to 0.86). There was no advantage in the second year of trastuzumab.
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