This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adaptive randomization of Veliparib–Carboplatin treatment in breast cancer. N Engl J Med 2016; 375: 23-34.
Published: 25th August 2016
Authors: Rugo HS, Olopade OI, DeMichele A, Yau C, van’t Veer LJ, Buxton MB et al.
Conclusion
Adaptive randomization was used to compare veliparib-carboplatin with standard therapy. The new combination was highly likely to result in higher rates of pathological complete response than standard chemotherapy in this study that included 116 women: complete pathological response 51 per cent compared to 26 per cent in controls.
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