This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Anastrozole versus tamoxifen in postmenopausal women with ductal carcinoma in situ undergoing lumpectomy plus radiotherapy (NSABP B-35): a randomised, double-blind, phase 3 clinical trial. Lancet 2016; 387: 849-856.

Published: 4th February 2016

Authors: Margolese RG, Cecchni RS, Julian TB, Ganz PA, Costantino JP, Vallow LA et al.

Conclusion

Some 2980 postmenopausal women were included and followed for a median of 7.2 years. There was no significant difference in the rate of breast cancer recurrence with anastrozole: hazard ratio 0.89, 95 per cent confidence interval 0.64 to 1.23. Adverse event rates were similar.

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