This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial. Lancet 2016; 387: 866-873.

Published: 4th February 2016

Authors: Forbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy C et al.

Conclusion

Some 3104 women with hormone receptor positive tumours were originally included and followed for a median of nine years. Anastrozole resulted in improved breast cancer survival: hazard ratio 0.73, 95 per cent confidence interval 0.56 to 0.96, P=0.02. The difference was only in women under 60 years of age.

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