This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 2006; 367: 1665¿1673.

Published: 1st January 2006

Authors: The ESPRIT Study Group.

Conclusion

The trial included over 1700 patients within six months of a TIA or stroke, and followed for a mean of 3.5 years. The addition of dipyridamole reduced the rate of subsequent cardiovascular events from 16 to 13 per cent: hazard ratio 0.8, 95 per cent confidence interval 0.66 to 0.98.

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